DC is actually a derivative of one of the starting chemicals (cyanamide) used in creatine production. DC is formed during the production of creatine products, and large amounts found in a product are considered the result of an incomplete or inefficient process. A quality creatine product will contain very small amounts, less than 20-50ppm. At this time, DC does not appear to be a particularly toxic chemical. Oral studies with animals (rats and dogs) lasting up to 90 days have not shown serious toxicity or carcinogenic effects, and acute poisoning also takes very high amounts. DC appears to have many uses in the chemical industry. Some of the more interesting is the use of DC in the production of fertilizers, explosives, fire proofing compounds, cleaning compounds, soldering compounds, stabilizer in detergents, modifier for starch products, and a catalyst for epoxy resins. At the concentrations found in some of the creatine products (see below), it's a good thing this stuff does not appear to be particularly toxic. However, as far as I am concerned, I don't want to be eating the stuff. One interesting point as it relates to DC and toxicity is, if one looks at the safety sheet on the stuff it states that DC breaks down into hydrogen cyanide gas when exposed to a strong acid. Hydrogen cyanide gas is very toxic and has been used as a chemical warfare agent!
As Bruce Kneller points out (see side bar), stomach acid, which has a PH of 2, is a very strong acid. Is even a tiny amount of hydrogen cyanide gas produced from the intake of large amounts of DC? The chemist I spoke to did not seem to think so and the safety data with animals would tend to support this, but who knows. Bruce might be overreacting a bit on this, but it’s better to lean on the cautious side with such things. Bottom line, it’s best not to be eating large amounts of DC in this writer’s opinion.
Dihydrotriazine (DT): DT appears to be the real mystery chemical as far as potentially toxic contaminants found in some creatine products. One company had it listed as “…Dihydrotriazine is often found in various creatine products. This substance is a byproduct of non-optimized creatine productions and consequently widely spread over creatine products. Dihydrotriazine is a compound with unknown pharmaceutical and toxicological properties." It was virtually impossible to find any useful safety data on this chemical. However, DT is part of a large family of chemicals known as the “triazines.” It is an organic base with many derivatives. Some of these derivatives are toxic while others are known to be non-toxic , so it is very difficult to come to any real solid opinion regarding the potential toxicity of this chemical. One chemist I spoke to from a major pharmaceutical supply company said to me on the phone "it's safe to say that there will be major differences in toxicity between derivatives since 'triazine' simply means possessing three C=N-H groups. Some derivatives are highly toxic.”
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